Immune Support - 120 Capsules

The immune system operates across multiple distinct pathways simultaneously: innate immunity (the immediate first-response), adaptive immunity (targeted antibody production), barrier integrity (gut and mucosal defences), and oxidative stress regulation (which both drives and suppresses immune function depending on balance). No single ingredient covers all four. The 19 actives in this formula are organised into four functional categories that map to these pathways: immunomodulators (Curcugen®, AP-Blo® Andrographis, Echinacea, Astragalus) that help regulate immune response up or down depending on need; antioxidants (Grape Seed, Bilberry, Quercetin, Vitamin C, Citrus Bioflavonoids, Rosemary) that reduce immune-suppressing oxidative load; antimicrobials (Garlzac® aged black garlic, Walnut Leaf, Olive Leaf, Oregano) that address pathogen burden directly; and adaptogenic mushrooms (Shiitake, Maitake, Cordyceps) that support NK cell activity and long-term immune resilience. Each ingredient earns its place by addressing a distinct function.

Standard curcumin (from turmeric) has very poor bioavailability, most of it is not absorbed from the gut and passes through unused. Curcugen® is a clinically validated curcumin complex developed by Gencor that delivers substantially higher plasma curcumin levels compared to standard 95% curcumin extracts, without requiring black pepper (piperine) to enhance absorption. Curcumin's role in immunity is as an immunomodulator and anti-inflammatory agent, it works by modulating NF-κB signalling, a central pathway in immune activation and inflammation. At the dose in this formula (250mg Curcugen® per 4-capsule serving), the systemic curcumin exposure is meaningfully higher than you'd get from an equivalent dose of standard curcumin. This matters particularly for sustained use, where the goal is consistent immune regulation rather than a short-term spike.

Vitamin C and Zinc address one dimension of immune support, antioxidant protection and immune cell function respectively. Both are important, and both are included in this formula (Vitamin C 80mg; Zinc is better addressed with iThrive Zinc Defense with Copper & L-Carnosine as a dedicated SKU). The difference is that Immune Support addresses the full breadth of immune function: the adaptogenic mushrooms (Shiitake, Maitake, Cordyceps) support NK cell activity and long-term immune modulation in a way that Vitamin C and Zinc alone cannot. Garlzac® aged black garlic and Olive Leaf Extract work as direct antimicrobials. AP-Blo® Andrographis and Echinacea are immunomodulators with clinical evidence for reducing duration of upper respiratory infections. Gentian and Oregano specifically target biofilm-forming organisms that resist standard immune clearance. This is a protocol, not a single-nutrient intervention.

Take all 4 capsules at the same time, preferably with food. The serving is designed as a single daily dose rather than a split dose. Taking with food improves tolerability of the herbal ingredients, particularly Andrographis and Gentian which can cause mild nausea on an empty stomach in sensitive individuals. If you're new to the formula or have a sensitive stomach, starting with 2 capsules daily for the first week and building to 4 is a sensible approach. The 120-capsule bottle gives you 30 days at the full dose or 60 days at a half-dose introductory approach.

Both, though the timing rationale differs slightly. For daily preventive use, the adaptogenic mushrooms (Shiitake, Maitake, Cordyceps) and immunomodulators work best taken consistently over 4-8 weeks, immune modulation is a slow process that requires sustained support. The NK cell activity benefits from medicinal mushrooms, for example, are documented over weeks of use, not days. For acute use when you feel illness coming on or are in a high-exposure period (travel, seasonal changes, stress), the antimicrobial ingredients (Garlzac®, Olive Leaf, Oregano) and Echinacea provide more immediate support. Many people in iThrive's ALIVE programme use this formula daily for 30 days, cycle off for 30 days, and repeat. This approach maintains immune resilience without the body habituating to any single botanical.

Yes - these three are frequently used together in iThrive ALIVE protocols, particularly during gut-clearing or post-illness recovery phases. Immune Support addresses the pathogen burden and immune response. Detox Binder helps clear the endotoxins and die-off compounds that are released when pathogens are disrupted. Probiotics reseed the gut microbiome after the clearing phase. If taking all three simultaneously, the practical sequencing most practitioners recommend is: Immune Support and Probiotics in the morning with food; Detox Binder in the evening at least 2 hours after other supplements. This prevents the activated charcoal in the binder from interfering with absorption of the botanical actives or probiotic cultures. Consult your practitioner if you are on prescription medication before starting any of these protocols.

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